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Many different variants in the MC4R gene are known to lead to early onset obesity in people. Excitingly, we have now been able to demonstrate that some variants have the opposite effect and may protect people from becoming overweight.
We recently described the mechanism through which Steroid Receptor Coactivator (SRC)-1 regulates appetite and body weight.
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University of Cambridge Metabolic Research Laboratories
Level 4, Institute of Metabolic Science
Box 289, Addenbrooke's Hospital
Cambridge, CB2 0QQ