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Some variants in the Melanocortin -4 Receptor (MC4R) may protect against obesity

Many different variants in the MC4R gene are known to lead to early onset obesity in people. Excitingly, we have now been able to demonstrate that some variants have the opposite effect and may protect people from becoming overweight.

 

Steroid Receptor Coactivator-1 modulates Pomc neurons involved in weight regulation

We recently described the mechanism through which Steroid Receptor Coactivator (SRC)-1 regulates appetite and body weight.

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